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Genomics · Genetic Reports · Precision Wellness

Fatigue

Personalized Genetic Report
Overall FatigueAnemia & Blood MarkersMental FatiguePhysical FatigueSleep DisturbancesFatigue Genes
Sample ClientReport date: 29 July 2026
Genomics · Genetic Reports · Precision Wellness
Marrow Health Laboratories
Marrow
Accession #: MRW-26-849AFD
Report type: Full Report
Report status: FINAL

Specimen and client information

Client
Sample Client
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
Accession
MRW-26-849AFD
Panel
Fatigue
Results scored
43
Need attention
7
Report
Full Report

What this report covers

Overall Fatigue · Anemia & Blood Markers · Mental Fatigue · Physical Fatigue · Sleep Disturbances · Fatigue Genes

About this report

This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.

What each result group means

Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.

Your results at a glance

How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 43 results here, 7 came back worth discussing with a clinician and 3 came back in your favour. Bring this document to your appointment.
Worth a conversation with your doctor  (7)These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
From your Fatigue report
ABrain Fog
More likely
Higher predisposition than 97% of people
CNR1 rs1049353 TT · MRPS9 rs181406718 GG · MRPS9 rs145642147 TT · ACTL7B rs190045124 GG · MRO rs143628339 TT
ASleep Apnea
More likely
Higher predisposition than 92% of people
LMX1A rs140743827 GG · GPR83 rs116791765 TT · NRG1 rs10097555 GA · ARRB1 rs35329661 CC · RGMA rs148024591 CC · UBE3A rs72699765 GG · PLCB1 rs2743173 CT · SLC35F3 rs75108997 GG
AFrailty
More likely
Higher predisposition than 89% of people
SYT14 rs12739243 TT · LRPPRC rs4952693 CC · RBM6 rs2071207 TT · TMOD2 rs17612102 CC · PIK3C3 rs8089807 CT · MDFIC rs2396766 AG · NLGN1 rs583514 CT · CCDC6 rs4146140 TC
ALow Mood
More likely
Higher predisposition than 85% of people
TCF4 rs1452787 AG · FKBP4 rs2302729 CC · TULP1 rs9296158 GG · FAM53B rs35936514 CC · ANKK1 rs1800497 GA · OXTR rs2254298 GA · FAAH rs324420 CA · TPH1 rs1799913 GT
ASnoring
More likely
Higher predisposition than 84% of people
TSHZ3 rs8108822 CC · MSRB3 rs10878269 TT · LGR4 rs2049045 GG · SNX11 rs11409890 TT · GATA3 rs725861 AG · ANAPC4 rs34811474 GA · BCL11B rs2664299 TC · XKR9 rs13251292 AG
AFibromyalgia
More likely
Higher predisposition than average
GALNT17 rs112477646 CC · ERBB4 rs200556109 GG
ALong COVID
More likely
Higher predisposition than average
PEDS1 rs6020298 GA · IL10RB rs8178562 AG · CXCR6 rs11385942 GG · ACE2 rs2285666 C
Running above the typical range  (6)Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
From your Fatigue report
HMCHC
Higher levels
Higher than 90% of people
SLC35B1 rs575705078 AA · TF rs150854910 CC · RAB7A rs112097551 GG · RBL1 rs149999468 GG · BORA rs184739375 TT · AAR2 rs181837942 AA · HBB rs34029390 AA · GREM2 rs142343894 GG
HHematocrit
Higher levels
Above the typical range
HBS1L rs9399137 CC · ABO rs2519093 TT · TMEM63B rs833805 GG · H1-7 rs2732469 AA · PRKAG2 rs10224210 TC · TMPRSS6 rs855791 AG · SH2B3 rs3184504 TC · SBF2 rs368417629 TG
HHemoglobin
Higher levels
Above the typical range
PIEZO1 rs551118 GG · ENG rs913987 GG · NRG4 rs4886755 GG · PRKAG2 rs10224210 TC · SH2B3 rs7137828 CT · NRIP1 rs1997595 CC · PPARG rs35240997 GG · NFIB rs17278406 GA
HFerritin
Higher levels
Above the typical range
MPO rs34523089 TC · VANGL1 rs10801913 AA · NKX3-1 rs13253974 AA · TMPRSS6 rs855791 AG · VEGFA rs36184164 GT · NOD1 rs2529440 CT · C11ORF21 rs12419620 TG · FUT3 rs708686 CT
HEndurance
Higher
Above the typical range
GABPB1 rs7181866 AA · GABPB1 rs8031031 CC · ACTN3 rs1815739 TC · SLC16A1 rs1049434 TT · KDR rs1870377 TT · PRDM1 rs10499043 CC · ADRB3 rs4994 AA · GSTP1 rs1695 AA
HDRD3 (Dopamine/Energy)
Higher activity
Above the typical range
DRD3 rs6280 TT
Running below the typical range  (4)Your genetics point to these sitting lower than average. Same idea — context, not alarm.
From your Fatigue report
LHeart Rate Recovery
Slower
Below the typical range
CAV1 rs1997571 GA · RGS6 rs17180489 CG · SERINC2 rs11589125 CC · NEGR1 rs61765646 TT · NEGR1 rs12740789 GG · SATB1 rs73043051 TT · PAX2 rs10748799 CT · RNF220 rs272564 AC
LTolerance to Exercise Intensity
Lower
Below the typical range
GABPB1 rs7181866 AA · GABPB1 rs8031031 CC · ADRB2 rs1042713 GA · CYBA rs4673 GA · PPARGC1A rs8192678 TC · AMPD1 rs17602729 GG · AGT rs699 GG · ACE rs4343 AA
LSLC6A4 (Fatigue, Mental Health)
Lower activity
Below the typical range
BLMH rs2066713 GG
LIL1B (Inflammation/ Fatigue)
Lower activity
Below the typical range
IL1A rs1143633 CC · IL1B rs1143634 GG
Working in your favour  (3)Good news. Your genetics look protective or better than average here.
From your Fatigue report
FMuscle Soreness
Less likely
Lower predisposition than 92% of people
ACTN3 rs1815739 TC · CCR2 rs1799865 TT
FPernicious Anemia
Less likely
Lower predisposition than average
FDaytime Sleepiness
Less likely
Lower predisposition than average
TMEM144 rs115320831 AA · AP3B2 rs17507216 GA · SLC24A3 rs565444861 GG · PTPRM rs558006880 GG · LBP rs6099524 CC · FGGY rs192315283 TT · TMEM132B rs142261172 GG
In line with most people  (23)Nothing unusual. These were tested and came back typical — worth having on record.
From your Fatigue report
·Anemia
Typical likelihood
In line with the general population · 70th percentile
ZDHHC14 rs181143083 TT · TMPRSS6 rs855791 AG · TRIM33 rs576432148 AA · TMPRSS6 rs228916 TT · IGLV4-60 rs987710 GG · RNF43 rs199598395 CC · VMP1 rs143341655 CC · MXRA8 rs138300056 CC
·MCH
Typical levels
In line with the general population · 60th percentile
H1-2 rs79220007 TT · RSRP1 rs114247628 GG · ATP2B4 rs7514742 AA · PIEZO1 rs551118 GG · DHRS13 rs9895443 AA · TMPRSS6 rs855791 AG · SIDT2 rs651821 TT · SLC4A1 rs13306780 AC
·Muscle Cramps
Typical likelihood
In line with the general population · 59th percentile
IKZF2 rs112988286 AA · MSI2 rs116924898 GG · LMO7 rs73229904 TT · TBC1D4 rs76851570 TT · STK32A rs35852718 AA · EPS8L2 rs201086107 GG · ST6GAL2 rs62155507 AA · RAB21 rs61754230 CC
·Low Energy (Chronic Fatigue)
Typical likelihood
In line with the general population · 58th percentile
MAPT rs242924 TT · IL17F rs763780 TT · DRD2 rs6277 GG · COMT rs4680 AG · ADRB2 rs1042714 GC · NR3C1 rs852977 GA · SPATA32 rs117228037 AA · SHISA4 rs2279681 CG
·Night Peeing
Typical likelihood
In line with the general population · 57th percentile
·Insomnia
Typical likelihood
In line with the general population · 47th percentile
ISL1 rs116701328 GG · SPATS2L rs75671770 GG · OLFM4 rs4884401 CC · OLFM4 rs79169188 GG · ZFP64 rs1033714 AA · ELAVL2 rs141890451 AA · OLFM4 rs9536382 CC · OLFM4 rs7996330 CC
·Restless Legs
Typical likelihood
In line with the general population · 27th percentile
GLO1 rs9296249 TT · GLO1 rs3923809 GA · HOXB2 rs12450895 AA · PTPRD rs62535767 CC · C1D rs1820989 CA · PIK3R4 rs35987657 AG · CRBN rs1848460 TA · SLC40A1 rs10188680 AT
·Iron
Typical need
In line with the general population
TMPRSS6 rs4820268 GA · TMPRSS6 rs855791 AG · TF rs3811647 AG · DTWD2 rs2442120 CC · SLC24A2 rs142401741 GG · IRX2 rs62330869 AA · HFE rs1799945 CC · SCGN rs115809796 AA
·Red Blood Cells
Typical levels
In line with the general population
PTPRC rs1434282 TT · TMEM72 rs2281841 CC · SBF2 rs368417629 TG · PPRC1 rs149687130 AA · TTC1 rs148871069 AA · EGLN2 rs184088518 GG · SLC9A3R2 rs139491786 CC · HCRTR2 rs4715517 CC
·Aplastic Anemia
Typical likelihood
In line with the general population
·TIBC
Typical levels
In line with the general population
SRPRB rs189613548 CC · RAB6B rs116711620 CC · TF rs2692666 GG · B3GNT2 rs144403535 AA · B3GNT2 rs186783840 CC · PHF14 rs145285408 GG · CSF3R rs142692454 AA · EPHB1 rs187472012 AA
·MPV
Typical levels
In line with the general population
GFI1B rs150813342 CC · CUX1 rs139141690 GG · TPM4 rs57843631 CC · STK38 rs113553570 GG · TNRC6A rs181042823 GG · CKAP2L rs76036957 GG · GPR35 rs78909033 GG · CCDC71L rs12535463 CC
·RDW
Typical levels
In line with the general population
SOX6 rs11023888 TT · TST rs5756491 AA · GPR84 rs79755767 GG · ANGPTL4 rs116843064 GG · ABO rs10793962 AA · PDCD5 rs34943133 GG · ABCB6 rs57467915 GG · LIPG rs77960347 AA
·MCV
Typical levels
In line with the general population
LMF2 rs140522 CC · HMGB1 rs9579583 CC · TMPRSS6 rs855791 AG · CEBPA rs78744187 CT · CITED2 rs592423 CA · RCL1 rs10758656 AG · CD164 rs1546723 AG · TF rs150854910 CC
·Exercise Recovery
Typical
In line with the general population
HGF rs5745678 GG · MYLK rs28497577 TT · IL6R rs2228145 CC · ACTN3 rs1815739 TC · CCR2 rs1799865 TT · SLC30A8 rs13266634 CC · CRP rs1205 CC · IL1B rs1143634 GG
·Aerobic Capacity (VO2 Max)
Typical
In line with the general population
SCN10A rs6801957 CC · TGM2 rs4811602 GG · ERBIN rs251295 GA · POLM rs10232743 CC · MOXD1 rs589756 AC · CCDC141 rs10497529 GG
·Muscle Recovery
Typical
In line with the general population
COL2A1 rs2070739 TC · COL5A1 rs12722 TC · TRIM63 rs2275950 CT · SOD2 rs4880 GG · CCR2 rs3918358 AA · CCL2 rs3917878 CC · TNF rs1800629 GG · IGF2 rs7924316 GG
·Caffeine-Related Sleep Problems
Typical likelihood
In line with the general population
ADORA2A rs5751876 CT · MDFIC2 rs7628219 CC · GBP7 rs521704 CA · ADGRL2 rs12725617 CT · PRIMA1 rs12895096 TG · LRTM1 rs11706236 AA · NEDD4L rs158856 CC
·Sleep Movement
Typical likelihood
In line with the general population
GLO1 rs3923809 GA · TOX3 rs3104788 TC · MEIS1 rs113851554 GG
·Narcolepsy
Typical likelihood
In line with the general population
ASAH2B rs4290173 CC · HLA-DQA2 rs2858884 AA · CCR2 rs3181077 TT · DAD1 rs1154155 TT · CPT1B rs5770917 TT · ADO rs10995245 GG · LMCD1 rs1027327 AA · GJB4 rs10915020 TT
·TMPRSS6 (Iron)
Typical activity
In line with the general population
TMPRSS6 rs4820268 GA · TMPRSS6 rs855791 AG · TMPRSS6 rs228916 TT
·NR3C1 (Fatigue)
Intermediate activity
In line with the general population
NR3C1 rs6196 AA · NR3C1 rs852977 GA · NR3C1 rs1866388 GA · NR3C1 rs6188 AC
·TF (Iron & Cognition)
Typical activity
In line with the general population
TF rs1049296 CC

Methodology

Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.

Limitations

This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.

Performing laboratory & attestation
Performing laboratoryGene by Gene, Ltd.
Laboratory address1445 North Loop West, Suite 760, Houston, TX 77008
CLIA certificationCLIA #45D1102202
CAP accreditationCAP #7212851 · accredited through 7 October 2027
Laboratory DirectorFeng Zhou, PhD, MB(ASCP)
Specimen typeBuccal (cheek) swab — genomic DNA
AccessionMRW-26-849AFD
Date reported29 July 2026

This specimen was tested at Gene by Gene, Ltd., 1445 North Loop West, Suite 760, Houston, TX 77008, under CLIA #45D1102202 and CAP #7212851. Laboratory Director: Feng Zhou, PhD, MB(ASCP). Marrow Health is not a clinical laboratory and does not perform testing; Marrow prepares and delivers this report from data produced by the performing laboratory named above. Report generated 29 July 2026 · Accession MRW-26-849AFD · © 2026 Marrow Health.