Marrow
Genomics · Genetic Reports · Precision Wellness

Inflammation & Autoimmunity

Personalized Genetic Report
Inflammatory Gut ConditionsOther Inflammatory ConditionsAutoimmune Joint ConditionsAutoimmune Skin ConditionsOther Autoimmune ConditionsInflammation MarkersHLA GenesOther Inflammation Genes
Sample ClientReport date: 29 July 2026
Genomics · Genetic Reports · Precision Wellness
Marrow Health Laboratories
Marrow
Accession #: MRW-26-0FCD26
Report type: Full Report
Report status: FINAL

Specimen and client information

Client
Sample Client
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
Accession
MRW-26-0FCD26
Panel
Inflammation & Autoimmunity
Results scored
80 of 83
Need attention
9
Report
Full Report

What this report covers

Inflammatory Gut Conditions · Other Inflammatory Conditions · Autoimmune Joint Conditions · Autoimmune Skin Conditions · Other Autoimmune Conditions · Inflammation Markers · HLA Genes · Other Inflammation Genes

About this report

This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.

What each result group means

Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.

Your results at a glance

How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 80 results here, 9 came back worth discussing with a clinician and 6 came back in your favour. Bring this document to your appointment.
Worth a conversation with your doctor  (9)These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
From your Inflammation & Autoimmunity report
ATonsil Inflammation
More likely
Higher predisposition than 99% of people
AThyroid Inflammation
More likely
Higher predisposition than 96% of people
TRIB2 rs1534422 GG · SESN3 rs4409785 TC · ZNF668 rs57348955 AG · TNFRSF14 rs2843403 TC · PTPN22 rs2476601 GG · PTPN22 rs6679677 CC · CTLA4 rs11571297 TT · TNF rs1800629 GG
APancreas Inflammation
More likely
Higher predisposition than 95% of people
SPINK5 rs112861203 TT · STK32A rs148849032 CC · MORC4 rs12688220 C · JAKMIP2 rs146303903 AA · CTRC rs497078 CC · STK32A rs142623619 AA · ADRB2 rs17640347 GG · ABCG5 rs75331444 GG
AUrethra Inflammation
More likely
Higher predisposition than 88% of people
AEye Inflammation
More likely
Higher predisposition than 84% of people
EYS rs665873 AA · IL23R rs79755370 CC · ERAP1 rs2032890 AA · B3GNT2 rs4672507 TT · IL10 rs17351243 AA · INAVA rs12132349 TA · IL18R1 rs10197284 GA · IL6R rs6690230 GG
ACrohn’s Disease
More likely
Higher predisposition than 66% of people
SLC23A1 rs10063949 CC · ATG16L1 rs2241880 GG · STAT3 rs744166 AA · SLC22A5 rs12521868 TT · JAK2 rs10758669 CA · IL23R rs11465804 TT · IRGM rs1000113 TC · PPM1M rs5743836 GG
APsoriasis
More likely
Higher predisposition than 65% of people
TYK2 rs34536443 GG · IL23R rs9988642 TT · STAT2 rs2066819 CC · IL12B rs7709212 TT · SLC22A5 rs1295685 GG · PPP2R3C rs8016947 GG · TSC22D1 rs9533962 CC · POLI rs545979 TT
AMyocarditis
More likely
Higher predisposition than average
ANephritis
More likely
Higher predisposition than average
PLA2R1 rs4664308 AA · HLA-DQA1 rs2187668 CC · MICB rs3134792 TT · MICB rs7775397 TT · MICB rs389884 AA · MICB rs7750641 CC · MICB rs3130544 CC · HLA-DMB rs1480380 CC
Running above the typical range  (8)Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
From your Inflammation & Autoimmunity report
HHLA (Inflammation)
Higher activity
Higher than 80% of people
HLA-DRB1 rs2516049 CT · HLA-DQA2 rs9275524 CT · HLA-C rs13202464 AA · MICA rs116488202 CC · TAP2 rs2071479 CC
HBasophils
Higher levels
Above the typical range
GATA2 rs6782812 AA · CEBPA rs78744187 CT · CEBPG rs12151289 GC · LARP4B rs11253511 TC · FCGR2B rs2994672 CT · GFI1B rs550065584 GG · TENT5A rs559377462 CC · LPO rs546552332 AA
HHLA-DOB (Inflammation)
Higher activity
Above the typical range
HLA-DOB rs10484565 GA · HLA-DQA1 rs9784858 GC · TAP2 rs2071479 CC
HNF-kB (Inflammation)
Higher activity
Above the typical range
NFKBIE rs2233434 GA · HLA-C rs2230365 CC · DDX39B rs2255798 GG
HNLRP3 (Gut Inflammation)
Higher activity
Above the typical range
NLRP3 rs3806265 CC · NLRP3 rs3738447 GG · NLRP3 rs4925648 CC
HANKRD55 (Autoimmune)
Higher activity
Above the typical range
ANKRD55 rs71624119 GG · ANKRD55 rs7731626 GG · ANKRD55 rs10065637 CC · ANKRD55 rs10040327 CC
HABCB1 (Chronic Lyme)
Higher activity
Above the typical range
ABCB1 rs1128503 GG
HHNMT (Histamine)
Higher activity
Above the typical range
HNMT rs11558538 CC
Running below the typical range  (7)Your genetics point to these sitting lower than average. Same idea — context, not alarm.
From your Inflammation & Autoimmunity report
LSH2B3 (Autoimmunity)
Lower activity
Below the typical range
SH2B3 rs653178 CT · SH2B3 rs597808 AA
LHNF4A (Gut Inflammation)
Lower activity
Below the typical range
HNF4A rs6017342 CC
LCTLA4 (Autoimmunity)
Lower activity
Below the typical range
CTLA4 rs11571302 GG · CTLA4 rs231779 CT
LIL1B (Inflammation/ Fatigue)
Lower activity
Below the typical range
IL1A rs1143633 CC · IL1B rs1143634 GG
LJAK2 (Gut Inflammation)
Lower activity
Below the typical range
JAK2 rs10758669 CA · JAK2 rs12340895 CC
LIL8 (Inflammation)
Lower activity
Below the typical range
PF4V1 rs4073 TT
LIL21 (Autoimmunity & Allergies)
Lower activity
Below the typical range
IL21 rs6822844 TG · IL21 rs907715 TC · KIAA1109 rs13119723 GA · KIAA1109 rs2221903 TT
Working in your favour  (6)Good news. Your genetics look protective or better than average here.
From your Inflammation & Autoimmunity report
FOptic Nerve Inflammation
Less likely
Lower predisposition than 81% of people
FGut Inflammation
Less likely
Lower predisposition than 92% of people
FCGR2A rs1801274 AA · ATG16L1 rs2241880 GG · STAT3 rs744166 AA · ADO rs10761659 AG · HNF4A rs6017342 CC · IL23R rs11465804 TT · HLA-DQA2 rs2395185 TG · IL23R rs10889677 CA
FAppendicitis
Less likely
Lower predisposition than 92% of people
TUB rs72848490 TC · MTARC1 rs3738182 GG · PITX2 rs7697491 TA · PITX2 rs13121924 GA · LTBR rs10849448 AG · OSR1 rs56259011 CC
FDiverticular Disease
Less likely
Lower predisposition than average
POLR3A rs139044580 GG · TBX5 rs2551395 TT · UPF2 rs78114187 CC · LYPLAL1 rs61823192 CC · SHANK1 rs113101273 GG · SOCS6 rs79586998 CC · LHFPL3 rs6980251 AC · YARS2 rs191699548 GG
FSjogren's Syndrome
Less likely
Lower predisposition than average
DDX6 rs7119038 AA · HLA-DQA2 rs9271588 CT · IL12A rs485497 AA · STAT4 rs10168266 CT · STAT4 rs10553577 TI · OLIG3 rs6933404 TC · CPEB4 rs359457 TC · PTTG1 rs2431098 GA
FIL6R (Weight)
Better genetics
Lower predisposition than average
IL6R rs4845623 GG · IL6R rs2228145 CC · IL6R rs2229238 CC
In line with most people  (50)Nothing unusual. These were tested and came back typical — worth having on record.
From your Inflammation & Autoimmunity report
·Ulcerative Colitis
Typical likelihood
In line with the general population · 63th percentile
STAT3 rs744166 AA · HNF4A rs6017342 CC · HLA-DQA2 rs2395185 TG · IL23R rs76418789 GG · IL23R rs11805303 CT · MFSD4B rs3851228 AA · NR5A2 rs2816958 GG · IL19 rs1800872 GG
·Multiple Sclerosis
Typical likelihood
In line with the general population · 60th percentile
EBPL rs9591325 TT · IL2RA rs2104286 TT · RBM17 rs11256593 TT · TYK2 rs34536443 GG · TAPBPL rs12832171 CC · JAK1 rs72922276 GG · RGS1 rs1323292 AA · RTEL1-TNFRSF6B rs6742 CC
·Stomach Inflammation
Typical likelihood
In line with the general population · 42th percentile
MRPL13 rs7826906 GA · CCDC66 rs6445797 GG · MTBP rs10955971 AG · CDC37 rs8112449 AG · TCP10L rs11088226 CC
·Celiac Disease
Typical likelihood
In line with the general population · 42th percentile
HLA-DRB5 rs2395182 TG · HLA-DQA2 rs7454108 TT · HLA-DQA1 rs2187668 CC
·Rheumatoid Arthritis
Typical likelihood
In line with the general population · 40th percentile
HLA-DQA2 rs6457617 TC · CTLA4 rs3087243 GG · ANKRD55 rs7731626 GG · ETS1 rs73013527 CC · RUNX1 rs8133843 AA · LBH rs7579944 CC · PODXL rs11761231 CC · ARID5B rs71508903 CT
·HRH4 (Allergies, Inflammation)
Typical activity
In line with the general population · 39th percentile
IMPACT rs524149 CC · HRH4 rs17797945 CC · HRH4 rs657132 GG · OSBPL1A rs527790 CC
·Inflammation (CRP)
Typical levels
In line with the general population · 36th percentile
CRP rs1205 CC · IL6R rs2228145 CC · FUT2 rs601338 AG · IL19 rs3024505 AG · IL4R rs1805011 AA · IL1RN rs419598 TT · ATG16L1 rs10210302 TT · ATG16L1 rs2241880 GG
·Eczema
Typical likelihood
In line with the general population · 29th percentile
IL6R rs61812598 AA · ADO rs4372325 CC · D2HGDH rs34290285 GG · ARHGAP27 rs9895436 AA · TREH rs10790275 CG · MDM1 rs2227491 TC · FLG rs138726443 GG · LINGO4 rs12123821 CC
·IL-6
Typical levels
In line with the general population · 20th percentile
ATP9A rs73273528 CC · SOX4 rs185628618 GG · TBKBP1 rs72831623 GG · TBKBP1 rs113600793 CC · IL6R rs4537545 TT · AKNA rs10982213 GG · SERPINE2 rs13412535 GA · CASS4 rs1884910 GC
·Type 1 Diabetes
Typical likelihood
In line with the general population · 15th percentile
IL19 rs3024505 AG · ERBB3 rs11171739 CT · RTL1 rs56994090 CT · DEXI rs12708716 GA · IL7R rs11954020 GG · MAPT rs1052553 AA · CLEC2D rs3764021 CT · TYK2 rs34536443 GG
·Lupus
Typical likelihood
In line with the general population · 12th percentile
IRF8 rs11644034 GG · NADSYN1 rs3794060 CC · PRDM1 rs6568431 AA · IKZF1 rs4917014 TT · LYST rs9782955 CC · ZFP36L1 rs4902562 AA · UBE2L3 rs7444 CT · SLU7 rs2431697 TC
·Chronic Lyme
Typical likelihood
In line with the general population
TLR2 rs5743708 GG · HLA-DQA2 rs6910071 GA · DDAH2 rs9267658 CT · HLA-DQA2 rs17208888 GG · TLR1 rs5743618 AA · ABCB1 rs1128503 GG · HLA-DOB rs3817964 TT · C6ORF47 rs4947332 CC
·Sepsis
Typical likelihood
In line with the general population
RIN3 rs149187226 GG · CHRM2 rs142021422 CC · KLHDC10 rs181021474 TT · MAD1L1 rs147296048 AA
·Pulmonary Fibrosis
Typical likelihood
In line with the general population
NCF2 rs17849502 GT · GLS rs13389408 TC · CCDC116 rs5754467 GA · TNFAIP3 rs58721818 CC · METTL27 rs193107685 TT · TNIP1 rs4958880 CC · IDUA rs13101828 AA · ALDH2 rs11066301 GA
·Actinic Keratosis
Typical likelihood
In line with the general population
BNC2 rs12350739 AG · HERC2 rs12916300 TC · FOXP1 rs7638354 TA · SLC45A2 rs16891982 GG
·Meningitis
Typical likelihood
In line with the general population
SGCD rs13358188 AA · SIK3 rs116886525 CC · ISL2 rs188530871 CC · CD28 rs189257688 CC · ITPKB rs17587821 TT · RCN1 rs61878814 TT · CACNA1E rs116306652 GG · RERE rs35608792 AA
·Sarcoidosis
Typical likelihood
In line with the general population
ZNF439 rs76054429 TT · PRRG4 rs143440435 TT · HLA-DMA rs9276935 TT · HLA-DQA2 rs3101944 CC · HLA-DRB1 rs28589559 GG · ZNF578 rs73575927 CT · TNR rs732292 AA · HLA-DRB1 rs9271346 TC
·Rheumatic Fever
Typical likelihood
In line with the general population
·Psoriatic Arthritis
Typical likelihood
In line with the general population
TYK2 rs34536443 GG · MICB rs13191343 TC · IL12B rs4921482 TT · STAT2 rs2020854 TT · IL12B rs62377586 GG · SLC22A5 rs848 CC · NXPE3 rs4683946 GG · CNTN4 rs17194140 TT
·Ankylosing Spondylitis
Typical likelihood
In line with the general population
IL23R rs11209026 GG · ERAP2 rs10045403 AA · NKX2-3 rs11190133 CC · ERAP1 rs30187 CT · CARD9 rs1128905 CC · INAVA rs41299637 TG · ETS2 rs2836883 AG · ERAP2 rs2910686 CT
·Vitiligo
Typical likelihood
In line with the general population
ASIP rs6059655 GG · HLA-A rs60131261 GG · DEF8 rs4268748 TT · IRF4 rs12203592 CC · TICAM1 rs4807000 AA · PTPRC rs16843742 TT · HLA-DQA2 rs9271597 AT · TYR rs1126809 AG
·Alopecia Areata
Typical likelihood
In line with the general population
PPARGC1A rs16873952 AA · NTM rs11600229 AA · CPVL rs505532 TT · ARHGAP42 rs11224294 CT · DISP3 rs3099624 CC · ST8SIA5 rs9952976 AA · CCDC24 rs304303 TG · ST3GAL3 rs4660260 TC
·Systemic Sclerosis
Typical likelihood
In line with the general population
GLS rs13389408 TC · CCDC116 rs5754467 GA · TNFAIP3 rs58721818 CC · TNPO3 rs13238352 CC · PTPN22 rs6679677 CC · TRIM59 rs112846137 GG · BLK rs2736337 TT
·Pemphigus Vulgaris
Typical likelihood
In line with the general population
EPHA5 rs1074532 AA · ANK2 rs362492 CC · UCN3 rs9423602 GG · SOX9 rs17246777 CC · CDH4 rs6093035 AA · ANKFN1 rs9899680 TT · PADI6 rs10888028 TT · STK32A rs62377684 TT
·Behcet’s Disease
Typical likelihood
In line with the general population
IL12A rs17810546 AA · CCR3 rs2087726 AA · IL23R rs6660226 GG · IL1A rs35145107 GG · B3GNT2 rs12467814 AA · PCGF3 rs4690319 GG · PLEKHH2 rs6544659 AA · IRF8 rs6540239 CT
·IgA Nephropathy
Typical likelihood
In line with the general population
NRBF2 rs57917667 GG · OVOL1 rs10896045 AA · IRF4 rs12201499 CC · HP rs10492815 AA · FAM91A1 rs34354351 TT · RREB1 rs12530084 CC · GPN3 rs56838584 GA · PSD3 rs2410596 CC
·TNF
Typical levels
In line with the general population
CRISPLD2 rs118135095 GG · TRIB2 rs116434579 GG · TNF rs1799724 TC · ROBO1 rs149420276 AG · TNF rs1800629 GG · SPRY1 rs115669577 GG · ERICH1 rs138808635 CC · PSD3 rs79105320 GG
·White Blood Cells
Typical levels
In line with the general population
PTPN22 rs2476601 GG · MICB rs2524079 AG · TET2 rs199741557 IA · JAML rs143034248 CC · TTC28 rs62237617 CC · ACKR1 rs34599082 CC · EHD3 rs184409696 GG · ORMDL3 rs4795415 CC
·Eosinophils
Typical levels
In line with the general population
GATA2 rs6782812 AA · SH2B3 rs7310615 GG · SLC22A5 rs2706334 TT · HLA-DQA2 rs28383314 CC · LGALS14 rs412884 CC · HBS1L rs9389268 GG · IL18R1 rs9807989 TC · KLF3 rs73232890 GA
·Monocytes
Typical levels
In line with the general population
LPAR1 rs115162333 TG · B3GNTL1 rs9902102 CC · CEBPG rs12151289 GC · CKM rs73036517 GA · IL17RA rs140221307 TT · FLT3 rs76428106 TT · GFI1 rs150649461 GG · TNFRSF13B rs34557412 AA
·Neutrophils
Typical levels
In line with the general population
ORMDL3 rs3826331 CC · LYST rs1886654 CC · CSF3R rs3917932 GG · NCLN rs144284241 CC · JAML rs143034248 CC · IFNA13 rs142938197 CC · DARS1 rs11548872 GG · PREX1 rs144582521 TT
·Erythrocyte Sedimentation Rate
Typical levels
In line with the general population
CD55 rs12034383 AG
·IgE
Typical levels
In line with the general population
ERMP1 rs928413 GG · FCER1A rs2251746 TT · STAT6 rs1059513 TT · NQO1 rs6499255 AA · ACKR1 rs13962 GG · LPP rs9290877 TC · IL13 rs20541 GG · SLC22A5 rs1800925 CC
·IL-10
Typical levels
In line with the general population
NNT rs140614282 GG · IKBIP rs1048911 TT · VEGFA rs4349809 GT · SHROOM3 rs143141511 GG · ZNF516 rs9951418 CC · SERPINE2 rs282258 TC · BMP2 rs6085948 GA · NFKBIE rs6458375 CT
·IL-17 (Th17)
Typical levels
In line with the general population
SHPRH rs182530774 CC · EPM2A rs187987903 GG · EPM2A rs13215785 GG · GRM1 rs117785887 TT · GRM1 rs35548402 AA · MCFD2 rs1446499 TT · TRIB3 rs62191444 GG · PCDH8 rs9568764 CG
·HLA-B (Autoimmune)
Typical
In line with the general population
HLA-C rs13202464 AA · MICA rs116488202 CC
·HLA-DQ (Inflammation)
Typical activity
In line with the general population
HLA-DQA2 rs9275596 CT · HLA-DQA2 rs9275572 AG · HLA-DQA2 rs9275524 CT · HLA-DQA1 rs2187668 CC
·HLA-DRB1 (Autoimmunity)
Typical
In line with the general population
HLA-DQA2 rs2395185 TG
·HLA-DQA2 (Inflammation)
Typical
In line with the general population
HLA-DQA2 rs9275524 CT
·TLR4 (Inflammation)
Typical activity
In line with the general population
TLR4 rs4986791 CC
·PTPN22 (Autoimmunity)
Typical
In line with the general population
PTPN22 rs2476601 GG
·DAO (Histamine)
Typical activity
In line with the general population
AOC1 rs1049793 GC · AOC1 rs1049742 CC · AOC1 rs2052129 GG
·STAT3 (Th1/Th17)
Typical activity
In line with the general population
STAT3 rs4796793 CC · STAT3 rs2293152 GC · STAT3 rs744166 AA
·TNF Gene (Inflammation)
Typical activity
In line with the general population
CRISPLD2 rs118135095 GG · TRIB2 rs116434579 GG · ATP10B rs149126334 GG · ANO3 rs10834997 GG · TNF rs1800629 GG · ERICH1 rs138808635 CC · GTF2E1 rs10511404 GG
·IL13 (Allergies, Lung Function)
Typical activity
In line with the general population
IL13 rs20541 GG · SLC22A5 rs1800925 CC · SLC22A5 rs1295686 CC · SLC22A5 rs848 CC
·IL4 (Allergies, Autoimmunity)
Typical activity
In line with the general population
SLC22A5 rs2243250 CC
·CRP Gene
Typical activity
In line with the general population
CRP rs1205 CC
·PADI4 (Autoimmune)
Typical activity
In line with the general population
PADI4 rs2240335 AC · PADI4 rs2301888 AG · PADI4 rs2240336 TC
·IL10 Gene (Autoimmunity)
Typical activity
In line with the general population
IL19 rs3024498 TT · FCMR rs3024493 AC · IL19 rs3024505 AG · IL19 rs3024496 GA · IL19 rs1800896 CT
·SLC22A4 (Gut Inflammation)
Typical genetics
In line with the general population
SLC22A4 rs1050152 TC

Methodology

Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.

Limitations

This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.

Performing laboratory & attestation
Performing laboratoryGene by Gene, Ltd.
Laboratory address1445 North Loop West, Suite 760, Houston, TX 77008
CLIA certificationCLIA #45D1102202
CAP accreditationCAP #7212851 · accredited through 7 October 2027
Laboratory DirectorFeng Zhou, PhD, MB(ASCP)
Specimen typeBuccal (cheek) swab — genomic DNA
AccessionMRW-26-0FCD26
Date reported29 July 2026

This specimen was tested at Gene by Gene, Ltd., 1445 North Loop West, Suite 760, Houston, TX 77008, under CLIA #45D1102202 and CAP #7212851. Laboratory Director: Feng Zhou, PhD, MB(ASCP). Marrow Health is not a clinical laboratory and does not perform testing; Marrow prepares and delivers this report from data produced by the performing laboratory named above. Report generated 29 July 2026 · Accession MRW-26-0FCD26 · © 2026 Marrow Health.