Marrow
Genomics · Genetic Reports · Precision Wellness

Metabolic Health

Personalized Genetic Report
Weight ControlBlood Sugar ControlThyroid HealthMiscellaneousMetabolism Genes
Sample ClientReport date: 29 July 2026
Genomics · Genetic Reports · Precision Wellness
Marrow Health Laboratories
Marrow
Accession #: MRW-26-1CC153
Report type: Full Report
Report status: FINAL

Specimen and client information

Client
Sample Client
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
Accession
MRW-26-1CC153
Panel
Metabolic Health
Results scored
58 of 61
Need attention
4
Report
Full Report

What this report covers

Weight Control · Blood Sugar Control · Thyroid Health · Miscellaneous · Metabolism Genes

About this report

This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.

What each result group means

Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.

Your results at a glance

How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 58 results here, 4 came back worth discussing with a clinician and 3 came back in your favour. Bring this document to your appointment.
Worth a conversation with your doctor  (4)These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
From your Metabolic Health report
ALow Blood Sugar
More likely
Higher predisposition than 99% of people
MTNR1B rs10830963 CG · GCK rs4607517 AG · URAD rs11619319 AA · TOP1 rs6072275 GG · GCKR rs780094 TC · FBRSL1 rs10747083 GG · PEAK1 rs7178572 AA · ZBED3 rs7708285 AA
AHeavy Sweating
More likely
Higher predisposition than 91% of people
LONP2 rs6500380 GG · SLC6A16 rs149876322 CG · PPP1CB rs56089836 CC · DLG2 rs12280544 CC · TLN2 rs139024759 AA · TUSC1 rs117093392 AA · UBLCP1 rs143772159 CC · FZD8 rs190252627 CC
AADRB2 (Weight)
Worse genetics
Higher predisposition than average
ADRB2 rs1042714 GC
ATCF7L2 (Blood Sugar/Diet)
Worse genetics
Higher predisposition than average
TCF7L2 rs7903146 CT · TCF7L2 rs12255372 GT
Running above the typical range  (6)Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
From your Metabolic Health report
HVisceral Fat
Higher levels
Higher than 82% of people
ADRB2 rs1042714 GC · MC4R rs2229616 CC · ADARB1 rs76040172 GG · ADH1B rs1229984 TC · RSPO3 rs9482772 CC · UHRF1BP1 rs9469899 AA · SEC16B rs539515 CA · SNX11 rs113866544 TC
HFOXO1 (Blood Sugar)
Higher activity
Above the typical range
MRPS31 rs17446614 GG · MRPS31 rs7986407 AA
HMTNR1B (Diet & Blood Sugar)
Higher activity
Above the typical range
HMC4R (Weight/ Blood Sugar)
Higher activity
Above the typical range
MC4R rs17782313 TT
HDIO1 (Thyroid)
Higher activity
Above the typical range
DIO1 rs2235544 CC
HDIO2 (Thyroid)
Higher activity
Above the typical range
DIO2 rs225014 TT
Running below the typical range  (9)Your genetics point to these sitting lower than average. Same idea — context, not alarm.
From your Metabolic Health report
LWeight Loss from Calorie Restriction
Lower
Below the typical range
ACSL5 rs2419621 CC · PPARG rs1801282 CC · GNAS rs6123837 AA · ADPGK rs7164727 TT · LMX1B rs10733682 AG · ETS2 rs2836754 TC · UCP1 rs1800592 TC · PPARG rs2959272 TT
LMetabolic Rate
Lower
Below the typical range
LEPR rs1805096 GG · PPARGC1A rs8192678 TC · LEPR rs1137101 AG · ADRB2 rs1042713 GA · LEPR rs1137100 AG · CCND2 rs76895963 TT · TP53 rs78378222 TT · PARD3B rs1470545 CC
LGLP-1
Lower levels
Below the typical range
RAPGEF4 rs150495482 CC · GPT rs139849083 CC · ADAP1 rs1568773 AA
LPostprandial Glucose
Lower levels
Below the typical range
LSLC30A8 (Blood Sugar)
Lower activity
Below the typical range
LUCP1 (Weight)
Lower activity
Below the typical range
LCDKN2B (Blood Sugar)
Lower activity
Below the typical range
CDKN2A rs10811661 TT · CDKN2B rs1063192 AA
LPPM1K (Blood Sugar/Diet)
Lower activity
Below the typical range
LMADD (Blood Sugar & Insulin)
Lower activity
Below the typical range
Working in your favour  (3)Good news. Your genetics look protective or better than average here.
From your Metabolic Health report
FOverweight
Less likely
Lower predisposition than 99% of people
LEPR rs1805096 GG · MC4R rs2229616 CC · TCF7L2 rs7903146 CT · NPY rs16147 TT · NEGR1 rs3101336 CC · ADRB2 rs1042713 GA · PEX11A rs894160 CT · NEGR1 rs2815752 AA
FMetabolic Syndrome
Less likely
Lower predisposition than 99% of people
TCF7L2 rs7903146 CT · MTNR1B rs10830963 CG · LPL rs328 CC · WSB2 rs7973260 AG · MLXIPL rs12056034 AG · TRIB1 rs2980888 TC · CLPTM1 rs483082 TG · GALNT2 rs2281721 CT
FFTO (Weight)
Better
Lower predisposition than average
FTO rs9939609 TT
In line with most people  (36)Nothing unusual. These were tested and came back typical — worth having on record.
From your Metabolic Health report
·Weight Regain
Typical likelihood
In line with the general population · 72th percentile
LEP rs4731426 GG · ALOX5AP rs4769873 CC · ALOX5AP rs9578196 CC · LEP rs2071045 TT · TUB rs7396690 GC · GCG rs3761656 TG · BDNF rs6265 TC · ALOX5AP rs9315051 AG
·Gout
Typical likelihood
In line with the general population · 58th percentile
SLC2A9 rs16890979 CC · SLC2A9 rs6449213 TT · SLC2A9 rs12498742 AA · SPP1 rs2728127 AA · TMEM171 rs520007 CC · TRMT112 rs2078267 TC · GCKR rs1260326 TC · MTX1 rs760077 TA
·Type 2 Diabetes
Typical likelihood
In line with the general population · 49th percentile
TCF7L2 rs7903146 CT · SLC30A8 rs13266634 CC · GCKR rs780093 CC · ADCY5 rs11708067 AA · IMPDH1 rs791595 AG · TNF rs2857605 TC · SLC38A11 rs10195252 TC · TSPAN3 rs7177055 GA
·Hashimoto's Disease
Typical likelihood
In line with the general population · 47th percentile
IL6 rs1800795 GG · CTLA4 rs34636506 AA · STAT4 rs11889341 CT · TPO rs11675434 CT · CTLA4 rs231775 AG · CD69 rs2110451 AG · RPS26 rs11611029 CT · NIPSNAP1 rs757024 GC
·Overactive Thyroid
Typical likelihood
In line with the general population · 46th percentile
CTLA4 rs3087243 GG · FCRL3 rs7522061 CT · TSHR rs12101261 CT · CD40 rs1883832 TC · MICB rs2517532 GA · FAM227B rs17477923 TT · PDE10A rs2983514 GG · PDE8B rs2046045 GT
·Insulin Resistance
Typical
In line with the general population · 43th percentile
FOXO3 rs13217795 TT · LEPR rs1137101 AG · HAPLN1 rs1457105 CC
·Underactive Thyroid
Typical likelihood
In line with the general population · 34th percentile
CTLA4 rs3087243 GG · TSHR rs12101261 CT · SH2B3 rs653178 CT · RASGRP1 rs12593201 AA · TPO rs732609 AC · SESN3 rs4409785 TC · CLECL1 rs370475698 IT · ARID5B rs71508903 CT
·Uric Acid
Typical levels
In line with the general population · 16th percentile
SLC17A1 rs2762353 GG · ABCA6 rs77542162 AA · ZKSCAN5 rs34670419 GG · UNCX rs13230509 CC · SLC39A8 rs13107325 CC · AAK1 rs12987661 TT · NRG4 rs4886755 GG · SLC16A9 rs1171614 CT
·Fasting Glucose
Typical levels
In line with the general population
GCKR rs780093 CC · CDKN2A rs10811661 TT · CETP rs708272 AA · IMPDH1 rs791595 AG · TNF rs2857605 TC · SLC38A11 rs10195252 TC · DGKB rs2191349 GT · PPARGC1A rs8192678 TC
·HbA1c
Typical levels
In line with the general population
HNRNPUL1 rs180958600 AA · G6PC2 rs560887 CC · GLP1R rs10305492 GG · MSTN rs191148279 GG · THADA rs41382648 CC · NUDCD3 rs1985469 TA · SLC30A8 rs13266634 CC · ADCY5 rs11708067 AA
·Insulin
Typical levels
In line with the general population
HDAC7 rs111264094 CC · PPARG rs11712037 CC · PPARG rs1801282 CC · RFC4 rs17300539 GG · FOXO3 rs2802292 GG · IGF1 rs860598 AA · BMP2 rs979012 TT · PPARGC1A rs8192678 TC
·Graves' Disease
Typical likelihood
In line with the general population
TSHR rs179247 AA · UHRF1BP1 rs9469899 AA · TSHR rs28414437 AC · TPO rs11675434 CT · IGLV3-21 rs5751536 GA · TSHR rs2300519 TA · CD40 rs1569723 CA · FCRL3 rs1977710 GA
·TSH
Typical levels
In line with the general population
LRRC6 rs117764941 GG · NFIA rs334725 AA · PDE8B rs2928167 AA · NR3C2 rs11732089 TT · TBX2 rs1157994 GG · FAM227B rs17477923 TT · VEGFA rs1317983 CT · TNP1 rs13020935 GA
·T3 (Triiodothyronine)
Typical levels
In line with the general population
FBLL1 rs590784 AC · SERPINA7 rs12687280 T · EPHB2 rs67142165 CC · RAB38 rs116951285 TT · PRKCE rs10192064 TT · MOV10L1 rs2066773 GG · VPS37B rs76465767 TT · AGPAT2 rs7020640 CC
·T4 (Thyroxine)
Typical levels
In line with the general population
MC4R rs56069042 AA · AADAT rs7694879 TC · SEPHS1 rs72783371 AA · CA8 rs67583169 CC · ILRUN rs73405691 AA · LRRC42 rs12127960 TA · H2BC1 rs9356988 AA · DIO2 rs225014 TT
·Free T4
Typical levels
In line with the general population
AADAT rs7694879 TC · ILRUN rs73405691 AA · H2BC1 rs9356988 AA · DIO2 rs225014 TT · SLCO1B1 rs4149056 TC · RNF144B rs10946313 TC · USP3 rs12907106 GC · NUCKS1 rs951366 TC
·Reverse T3 (rT3)
Typical levels
In line with the general population
DIO1 rs11206244 CC
·Free T3 (fT3)
Typical levels
In line with the general population
·Ketone Bodies
Typical levels
In line with the general population
SFT2D1 rs150515955 CC · GCKR rs780094 TC · GALNT2 rs4846915 CA · SIDT2 rs964184 CC
·Lactate
Typical levels
In line with the general population
HBS1L rs9376091 TT · SH2B3 rs7137828 CT · PFKP rs10794972 CA · SPATS2L rs59273177 AA · ALDH2 rs7138688 TT · TMX4 rs1473698 TT
·Creatine
Typical levels
In line with the general population
CPS1 rs1047891 AC · GATM rs2486274 GT · CCDC77 rs7307754 CT
·LEPR (Weight/Leptin Resistance)
Typical activity
In line with the general population
LEPR rs1137101 AG
·ADIPOQ (Weight/ Blood Sugar)
Typical genetics
In line with the general population
ADIPOQ rs2241766 GT
·UCP2 (Weight)
Typical activity
In line with the general population
·UCP3 (Weight)
Typical activity
In line with the general population
UCP3 rs1800849 GG
·ADRB3 (Weight)
Typical activity
In line with the general population
ADRB3 rs4994 AA
·CD36 (Fat Preference/Weight)
Typical activity
In line with the general population
CD36 rs1761667 AG
·TFAP2B (Weight/Diet)
Typical activity
In line with the general population
TFAP2B rs987237 AA
·PPARG (Metabolism)
Typical activity
In line with the general population
·APOA2 (Weight, Blood Lipids)
Typical activity
In line with the general population
FCER1G rs5082 AA
·MC3R (Weight)
Typical activity
In line with the general population
·TPO (Thyroid)
Typical
In line with the general population
TPO rs11675434 CT
·PPARGC1A (Fitness/Blood Sugar)
Typical activity
In line with the general population
PPARGC1A rs8192678 TC
·GCKR (Blood Sugar)
Typical activity
In line with the general population
GCKR rs780093 CC · GCKR rs1260326 TC · GCKR rs780094 TC
·GIPR (Blood Sugar)
Typical activity
In line with the general population
GIPR rs2287019 CC · GIPR rs10423928 TT
·PPARA (Keto Diet)
Typical activity
In line with the general population
PPARA rs1800206 CC

Methodology

Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.

Limitations

This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.

Performing laboratory & attestation
Performing laboratoryGene by Gene, Ltd.
Laboratory address1445 North Loop West, Suite 760, Houston, TX 77008
CLIA certificationCLIA #45D1102202
CAP accreditationCAP #7212851 · accredited through 7 October 2027
Laboratory DirectorFeng Zhou, PhD, MB(ASCP)
Specimen typeBuccal (cheek) swab — genomic DNA
AccessionMRW-26-1CC153
Date reported29 July 2026

This specimen was tested at Gene by Gene, Ltd., 1445 North Loop West, Suite 760, Houston, TX 77008, under CLIA #45D1102202 and CAP #7212851. Laboratory Director: Feng Zhou, PhD, MB(ASCP). Marrow Health is not a clinical laboratory and does not perform testing; Marrow prepares and delivers this report from data produced by the performing laboratory named above. Report generated 29 July 2026 · Accession MRW-26-1CC153 · © 2026 Marrow Health.