Marrow
Genomics · Genetic Reports · Precision Wellness

Fatigue

Personalized Genetic Report
Overall FatigueAnemia & Blood MarkersMental FatiguePhysical FatigueSleep DisturbancesFatigue Genes
Sample ClientReport date: 29 July 2026
Genomics · Genetic Reports · Precision Wellness
Marrow Health Laboratories
Marrow
Accession #: MRW-26-849AFD
Report type: Summary Report
Report status: FINAL

Specimen and client information

Client
Sample Client
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
Accession
MRW-26-849AFD
Panel
Fatigue
Results scored
43
Need attention
7
Report
Summary Report

What this report covers

Overall Fatigue · Anemia & Blood Markers · Mental Fatigue · Physical Fatigue · Sleep Disturbances · Fatigue Genes

About this report

This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.

What each result group means

Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.

Your results at a glance

How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 43 results here, 7 came back worth discussing with a clinician and 3 came back in your favour. Bring this document to your appointment.

What this package looks at

Fatigue — Sluggish, can’t think straight, and tired most of the day? Or is it just at certain times? Fatigue is a normal part of life, but it can also be a serious health issue. Chronic fatigue is one of those things that is easy to brush off, because, “Hey! Everyone gets tired.” However, chronic fatigue is a

What you can actually do

These are ordered by how closely they relate to your flagged results — not generic health advice. Marrow does not prescribe, dose, or tell you to take anything. Diet and lifestyle changes are listed first because they are yours to make. Anything you would swallow is listed separately, by name only, as something to raise with a clinician who knows your history and your medications.

Changes you can make yourself

1
Psychotherapy

Schedule and attend regular sessions with a licensed psychotherapist, typically once a week for 50-60 minutes, TA over a period of several months to years depending on your individual needs and progress.

Relates to: Low Mood, Fibromyalgia, Long COVID
relevance
2
Cognitive-Behavioral Therapy (CBT)

Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.

Relates to: Low Mood, Fibromyalgia, Brain Fog
relevance
3
Sleep for 7+ Hours

Ensure you allocate enough time in your schedule to achieve a minimum of 7 hours of sleep each night.

Relates to: Brain Fog, Low Mood, Heart Rate Recovery
relevance
4
Interpersonal Therapy50 minutes

Engage in weekly 50-minute sessions with a certified therapist trained in interpersonal therapy for a duration of TA 12-16 weeks.

Relates to: Low Mood
relevance
5
Psychodynamic Therapy

Schedule and attend weekly sessions with a trained psychodynamic therapist for a minimum duration of 6 months to several years, depending on individual needs and progress.

Relates to: Low Mood
relevance
6
Sunlight Exposure20 minutes

Expose your skin to direct sunlight for about 10-30 minutes several times per week, preferably during midday TA when the sun is strongest.

Relates to: Low Mood
relevance
7
Strength Training

Engage in strength training exercises, such as weight lifting or bodyweight exercises, for 60 minutes per session, TA 2 to 3 times per week.

Relates to: Low Mood, Heart Rate Recovery, Frailty
relevance
8
Yoga30 minutes

Practice yoga for at least 20 to 30 minutes a day, most days of the week.

Relates to: Low Mood, Brain Fog, Fibromyalgia
relevance
9
Meditation30 minutes

Meditation Breathing exercises Yoga-based coping instructions Group discussions Those who practiced yoga more often were more likely to benefit more.

Relates to: Low Mood, Brain Fog, Fibromyalgia, Heart Rate Recovery
relevance
10
Acupuncture

Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.

Relates to: Sleep Apnea, Low Mood, Long COVID, Fibromyalgia
relevance
11
Progressive Muscle Relaxation10 minutes

TA the muscles in your feet for 5 seconds, then relax for 30 seconds, and progressively work your way up through the major muscle groups of your body, tensing then relaxing each for 5 and 30 seconds respectively.

Relates to: Low Mood, Fibromyalgia, Sleep Apnea
relevance
12
Mediterranean Diet

Limit red meat to a few times a month and include a moderate amount of dairy products.

Relates to: Frailty, Low Mood, Fibromyalgia, Sleep Apnea
relevance
13
Mindfulness Meditation30 minutes

TA focus on your breath, observing thoughts and sensations without judgment.

Relates to: Low Mood
relevance

Worth asking your clinician about

These came up in the research behind your flagged results. They are listed by name so you can ask about them. Marrow is not recommending them, and gives no dose. Supplements interact with prescription medication and with each other — that conversation belongs with your clinician.

1
Acetyl-L-Carnitine
Relates to: Low Mood, Fibromyalgia, Brain Fog
relevance

Your headline findings

Of the 43 results in this package, these 7 came back furthest from the population average. Each one below explains what it is, where you sit, and which report it came from. Start here.

Brain FogMore likely
More likely to have brain fog based on 5,554 genetic variants we looked at
Your risk is greater than 97% of the population and lower than 3% of the population.

What this actually is

Key Takeaways: Brain fog is a common symptom of chronic fatigue syndrome.

It manifests as memory problems, difficulty focusing, jumbled or hazy thoughts, and confusion.

Risk factors include stress, sleep problems, air pollution, smoking, and your genetics.

What you can do

  • Sleep for 7+ Hours
    Ensure you allocate enough time in your schedule to achieve a minimum of 7 hours of sleep each night.
  • Yoga 30 minutes
    Practice yoga for at least 20 to 30 minutes a day, most days of the week.
  • Meditation 30 minutes
    Meditation Breathing exercises Yoga-based coping instructions Group discussions Those who practiced yoga more often were more likely to benefit more.
From your Fatigue report
Sleep ApneaMore likely
More likely to have sleep apnea based on 1,227,186 genetic variants we looked at
Your risk is greater than 92% of the population and lower than 8% of the population.

What this actually is

Key Takeaways: About 10-40% of differences in people's chances of developing sleep apnea may be due to genetics.

Other important risk factors include being male, older, overweight, nasal congestion issues, a smoker, and drinking alcohol.

Sleep apnea is a disorder that interrupts your breathing while you sleep.

What you can do

  • Acupuncture
    Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.
  • Meditation 30 minutes
    Meditation Breathing exercises Yoga-based coping instructions Group discussions Those who practiced yoga more often were more likely to benefit more.

Ask your clinician about

  • Maintain Optimal Vitamin D Levels

Named only. Marrow gives no dose and does not recommend these.

From your Fatigue report
FrailtyMore likely
More likely to experience frailty based on 16,767 genetic variants we looked at
Your risk is greater than 89% of the population and lower than 11% of the population.

What this actually is

The clinical presentation of frailty includes symptoms such as fatigue, muscle weakness, slowed performance, and diminished energy reserves.

Due to its multidimensional nature, the diagnosis of frailty involves a comprehensive assessment of physical capability, nutritional status, and social and psychological functions.

Management strategies for frailty are typically multidisciplinary and can include tailored exercise programs to improve physical function, nutritional interventions to address potential deficiencies or undernutrition, and supportive measures to enhance social support and cognitive stimulation.

What you can do

  • Mediterranean Diet
    Limit red meat to a few times a month and include a moderate amount of dairy products.
  • Strength Training
    Engage in strength training exercises, such as weight lifting or bodyweight exercises, for 60 minutes per session, TA 2 to 3 times per week.

Ask your clinician about

  • Maintain Optimal Vitamin D Levels

Named only. Marrow gives no dose and does not recommend these.

From your Fatigue report
Low MoodMore likely
More likely to have chronically low mood based on 84,205 genetic variants we looked at
Your risk is greater than 85% of the population and lower than 15% of the population.

What this actually is

Key Takeaways: About 40% of differences in people's odds of developing depression may be due to genetics.

It is more likely for young adults and the elderly but can affect people of all ages.

Other risk factors include traumatic and stressful events, serious medical conditions, and substance use problems.

What you can do

  • Psychotherapy
    Schedule and attend regular sessions with a licensed psychotherapist, typically once a week for 50-60 minutes, TA over a period of several months to years depending on your individual needs and progress.
  • Cognitive-Behavioral Therapy (CBT)
    Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.
  • Interpersonal Therapy 50 minutes
    Engage in weekly 50-minute sessions with a certified therapist trained in interpersonal therapy for a duration of TA 12-16 weeks.
From your Fatigue report
SnoringMore likely
More likely to snore based on 1,021,845 genetic variants we looked at
Your risk is greater than 84% of the population and lower than 16% of the population.

What this actually is

Snoring is a common issue of disrupted breathing during sleep due to restricted airways.

A variety of factors can influence susceptibility to snoring, including your genetics.

While snoring once in a while usually isn’t a serious problem, regular snoring can disrupt your sleep.

What you can do

  • Singing 20 minutes
    Dedicate at least 20 minutes to singing daily, choosing songs that you enjoy and that allow for a range of vocal TA expressions.
From your Fatigue report
FibromyalgiaMore likely
More likely to have fibromyalgia based on 1,457,603 genetic variants we looked at

What this actually is

Factors that might increase the risk of developing fibromyalgia include: Gender, with women being diagnosed far more often than men Other diseases, such as lupus or rheumatoid arthritis Traumatic events or injuries Repetitive injuries due to certain jobs or activities Viral infections Genetics There is evidence to suggest that fibromyalgia has a genetic component.

People with a family history of fibromyalgia are more likely to develop the condition.

Studies have pointed to genes involved in the way the body processes pain signals, brain chemicals, and stress.

What you can do

  • Psychotherapy
    Schedule and attend regular sessions with a licensed psychotherapist, typically once a week for 50-60 minutes, TA over a period of several months to years depending on your individual needs and progress.
  • Cognitive-Behavioral Therapy (CBT)
    Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.

Ask your clinician about

  • Acetyl-L-Carnitine

Named only. Marrow gives no dose and does not recommend these.

From your Fatigue report
Long COVIDMore likely
More likely to have long COVID-19 based on 9 genetic variants we looked at

What this actually is

Organ damage could play a role in long COVID.

People who had severe COVID-19 illness might experience organ damage affecting the heart, kidneys, skin, or brain.

The effects could also lead to the development of new conditions, such as diabetes or a heart or nervous system condition.

What you can do

  • Psychotherapy
    Schedule and attend regular sessions with a licensed psychotherapist, typically once a week for 50-60 minutes, TA over a period of several months to years depending on your individual needs and progress.
  • Acupuncture
    Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.

Ask your clinician about

  • Maintain Optimal Vitamin D Levels

Named only. Marrow gives no dose and does not recommend these.

From your Fatigue report

Where your genetics are working for you

Not everything in a genetic report is a warning. These came back protective or better than average.

Muscle SorenessLess likely
Less likely to experience muscle soreness based on 6 genetic variants we looked at
Your risk is greater than 8% of the population and lower than 92% of the population.

What this actually is

Management of muscle soreness includes: Rest: Allowing muscles time to recover is crucial; gentle stretching can also help.

Proper nutrition and hydration: Eating a balanced diet rich in antioxidants and staying hydrated can support muscle recovery.

Ice Packs: Applying ice packs in the first 24-72 hours can help reduce inflammation.

From your Fatigue report
Pernicious AnemiaLess likely
Lower predisposition than average

What this actually is

Pernicious anemia variety of symptoms These include: Fatigue and Pale or Heart Shortness of Nerve problems weakness, and Mental problems behavioral Glossitis and Left untreated, it The primary administration of frequently (often stabilize.

For administration may intake is not reduced dietary Regular monitoring vitamin B12 levels help prevent adjustments to foods or alone cannot lacking.

From your Fatigue report
Daytime SleepinessLess likely
Less likely to experience daytime sleepiness based on 999,088 genetic variants we looked at

What this actually is

Daytime sleepiness is the feeling of excessive sleepiness during the day.

People with excessive daytime sleepiness often complain of not feeling well-rested, having difficulty waking up, or accidentally falling asleep during the day, among others [R, R, R].

Daytime sleepiness is usually a consequence of poor sleep duration or quality.

From your Fatigue report

Everything else that came back

The remaining results, grouped by what they mean. Every one of these is explained in full — with the genes and variants behind it — in the technical version of this report.

Running above the typical range  (6)
  • MCHC — Higher levels, 90th percentile
  • Hematocrit — Higher levels
  • Hemoglobin — Higher levels
  • Ferritin — Higher levels
  • Endurance — Higher
  • DRD3 (Dopamine/Energy) — Higher activity
Running below the typical range  (4)
  • Heart Rate Recovery — Slower
  • Tolerance to Exercise Intensity — Lower
  • SLC6A4 (Fatigue, Mental Health) — Lower activity
  • IL1B (Inflammation/ Fatigue) — Lower activity
In line with most people  (23)
  • Anemia — Typical likelihood, 70th percentile
  • MCH — Typical levels, 60th percentile
  • Muscle Cramps — Typical likelihood, 59th percentile
  • Low Energy (Chronic Fatigue) — Typical likelihood, 58th percentile
  • Night Peeing — Typical likelihood, 57th percentile
  • Insomnia — Typical likelihood, 47th percentile
  • Restless Legs — Typical likelihood, 27th percentile
  • Iron — Typical need
  • Red Blood Cells — Typical levels
  • Aplastic Anemia — Typical likelihood
  • TIBC — Typical levels
  • MPV — Typical levels
  • RDW — Typical levels
  • MCV — Typical levels
  • Exercise Recovery — Typical
  • Aerobic Capacity (VO2 Max) — Typical
  • Muscle Recovery — Typical
  • Caffeine-Related Sleep Problems — Typical likelihood
  • Sleep Movement — Typical likelihood
  • Narcolepsy — Typical likelihood
  • TMPRSS6 (Iron) — Typical activity
  • NR3C1 (Fatigue) — Intermediate activity
  • TF (Iron & Cognition) — Typical activity

What to do with this

Genetics is a predisposition, not a verdict. The single most useful thing you can do with this document is take it to a clinician and talk through the flagged findings — especially any that line up with symptoms you already have or conditions that run in your family. Nothing here changes: your DNA is the same at 60 as it is today, so this report does not expire.

Methodology

Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.

Limitations

This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.

Performing laboratory & attestation
Performing laboratoryGene by Gene, Ltd.
Laboratory address1445 North Loop West, Suite 760, Houston, TX 77008
CLIA certificationCLIA #45D1102202
CAP accreditationCAP #7212851 · accredited through 7 October 2027
Laboratory DirectorFeng Zhou, PhD, MB(ASCP)
Specimen typeBuccal (cheek) swab — genomic DNA
AccessionMRW-26-849AFD
Date reported29 July 2026

This specimen was tested at Gene by Gene, Ltd., 1445 North Loop West, Suite 760, Houston, TX 77008, under CLIA #45D1102202 and CAP #7212851. Laboratory Director: Feng Zhou, PhD, MB(ASCP). Marrow Health is not a clinical laboratory and does not perform testing; Marrow prepares and delivers this report from data produced by the performing laboratory named above. Report generated 29 July 2026 · Accession MRW-26-849AFD · © 2026 Marrow Health.