Marrow
Genomics · Genetic Reports · Precision Wellness

Pain

Personalized Genetic Report
Chronic PainMusculoskeletal PainAcute PainHeadachesPain Genes
Sample ClientReport date: 29 July 2026
Genomics · Genetic Reports · Precision Wellness
Marrow Health Laboratories
Marrow
Accession #: MRW-26-A03659
Report type: Summary Report
Report status: FINAL

Specimen and client information

Client
Sample Client
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
Accession
MRW-26-A03659
Panel
Pain
Results scored
33
Need attention
12
Report
Summary Report

What this report covers

Chronic Pain · Musculoskeletal Pain · Acute Pain · Headaches · Pain Genes

About this report

This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.

What each result group means

Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.

Your results at a glance

How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 33 results here, 12 came back worth discussing with a clinician and 1 came back in your favour. Bring this document to your appointment.

What this package looks at

Pain — We all experience pain from time to time, from stubbing a toe to hurting our knee or having a migraine attack. What makes us all different is the amount of pain we experience and how we handle it. There are lots of reasons for that, one of which is your DNA!

What you can actually do

These are ordered by how closely they relate to your flagged results — not generic health advice. Marrow does not prescribe, dose, or tell you to take anything. Diet and lifestyle changes are listed first because they are yours to make. Anything you would swallow is listed separately, by name only, as something to raise with a clinician who knows your history and your medications.

Changes you can make yourself

1
Avoid Food Triggers

Try to limit caffeine to per day to avoid migraines.

Relates to: Migraines
relevance
2
Cognitive-Behavioral Therapy (CBT)

Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.

Relates to: Migraines, Chronic Pain, Fibromyalgia, Shoulder & Neck Pain
relevance
3
Biofeedback

Practice the techniques learned during sessions at home daily to improve symptoms and manage your condition.

Relates to: Diabetic Neuropathy, Chronic Pain, Migraines, Shoulder & Neck Pain
relevance
4
Exercise Therapy

Begin by consulting with a physical therapist to assess your condition and create a personalized exercise plan.

Relates to: Long COVID
relevance
5
Acupuncture

Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.

Relates to: Chronic Pain, Migraines, Long COVID, Shoulder & Neck Pain
relevance
6
Low-Level Laser Therapy (LLLT)

Use a low-level laser therapy device, as directed by its manual or a healthcare professional, on the affected area.

Relates to: Chronic Pain, Shoulder & Neck Pain, Diabetic Neuropathy, Fibromyalgia
relevance
7
Meditation30 minutes

Set aside 10-20 minutes each day in a quiet space without distractions to practice meditation.

Relates to: Migraines, Chronic Pain, Fibromyalgia, Long COVID
relevance
8
Massage30 minutes

Choose a type of TA massage that suits your specific needs, such as Swedish for relaxation or deep tissue for muscle tension.

Relates to: Shoulder & Neck Pain, Chronic Pain, Fibromyalgia, Facial Pain
relevance
9
Strength Training

Engage in strength training exercises, such as weight lifting or bodyweight exercises, for 60 minutes per session, TA 2 to 3 times per week.

Relates to: Shoulder & Neck Pain, Diabetic Neuropathy
relevance
10
Drink at Least 8 Glasses of Water a Day

Consume a total of at least (or approximately 1.9 liters) of water over the course of the day.

Relates to: Migraines, Painful Urination
relevance
11
Hydrogen Water

Drink 1.5 to 2 liters of hydrogen-rich water daily, spread out over the course of the day.

Relates to: Migraines, Long COVID, Painful Bladder Syndrome
relevance

Worth asking your clinician about

These came up in the research behind your flagged results. They are listed by name so you can ask about them. Marrow is not recommending them, and gives no dose. Supplements interact with prescription medication and with each other — that conversation belongs with your clinician.

1
Magnesium
Relates to: Migraines, Chronic Pain, Cluster Headaches, Fibromyalgia
relevance
2
Coenzyme Q10 (CoQ10)
Relates to: Migraines, Fibromyalgia, Diabetic Neuropathy, Long COVID
relevance
3
Riboflavin (Vitamin B2)
Relates to: Migraines, Facial Pain
relevance

Your headline findings

Of the 33 results in this package, these 8 came back furthest from the population average. Each one below explains what it is, where you sit, and which report it came from. Start here.

MigrainesMore likely
More likely to have migraines based on 109,603 genetic variants we looked at
Your risk is greater than 99% of the population and lower than 1% of the population.

What this actually is

Risk factors include: obesity, depression, stress, being female, blood vessel issues, brain chemical imbalances.

If you have a high genetic risk, take action on modifiable risk factors to help reduce overall risk.

About 16% of Americans regularly have migraines.

What you can do

  • Avoid Food Triggers
    Try to limit caffeine to per day to avoid migraines.
  • Cognitive-Behavioral Therapy (CBT)
    Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.

Ask your clinician about

  • Magnesium

Named only. Marrow gives no dose and does not recommend these.

From your Pain report
Facial PainMore likely
Higher predisposition than 98% of people
Your risk is greater than 98% of the population and lower than 2% of the population.

What this actually is

Diagnosing facial approach that can otolaryngologists, comprehensively and strategies could blocks, or surgery, For instance, sudden, severe resulting from Psychological also play pivotal the need for a plan.

What you can do

  • Biofeedback
    Practice the techniques learned during sessions at home daily to improve symptoms and manage your condition.
  • Acupuncture
    Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.

Ask your clinician about

  • Magnesium

Named only. Marrow gives no dose and does not recommend these.

From your Pain report
Ear PainMore likely
Higher predisposition than 94% of people
Your risk is greater than 94% of the population and lower than 6% of the population.

What this actually is

Ear pain may not itself; it can conditions that otalgia.

Sinus dental issues, and to the ear.

Diagnosis of the comprehensive exam, audiometric studies.

What you can do

  • Apply Heat 15 minutes
    Do this TA several times a day, ensuring there's at least a 1-hour interval between sessions to avoid skin damage.
  • Topical Peppermint Oil
    Do this no more than 2-3 times daily.
From your Pain report
Statin-Induced Muscle PainMore likely
More likely to have statin-induced muscle pain based on 38 genetic variants we looked at
Your risk is greater than 90% of the population and lower than 10% of the population.

What this actually is

The exact mechanism by which statins cause muscle injury is not completely understood, but it is believed to be related to the depletion of coenzyme Q10, a key component in muscle energy production, or effects on muscle cell membranes and protein synthesis.

Risk factors for developing statin-induced myopathy include higher statin dosages, advanced age, female sex, smaller body frame, concurrent use of certain medications, and pre-existing conditions such as kidney disease.

Most patients see improvement in symptoms after discontinuation of the statin, but the condition necessitates careful balancing of the benefits of cholesterol lowering against the discomfort and potential harm of muscle symptoms.

Ask your clinician about

  • Maintain Optimal Vitamin D Levels
  • Coenzyme Q10 (CoQ10)

Named only. Marrow gives no dose and does not recommend these.

From your Pain report
Painful UrinationMore likely
More likely to have painful urination based on 786,605 genetic variants we looked at
Your risk is greater than 88% of the population and lower than 12% of the population.

What this actually is

Apart from other conditions or obstruct the flow prostate issues hyperplasia (BPH) infections or contribute to Other contributors certain harsh soaps or crucial when depends on cause.

What you can do

  • Drink at Least 8 Glasses of Water a Day
    Consume a total of at least (or approximately 1.9 liters) of water over the course of the day.
  • Apply Heat 15 minutes
    Do this TA several times a day, ensuring there's at least a 1-hour interval between sessions to avoid skin damage.
From your Pain report
Shoulder & Neck PainMore likely
More likely to have shoulder and neck pain based on 924,669 genetic variants we looked at
Your risk is greater than 84% of the population and lower than 16% of the population.

What this actually is

Key Takeaways: About 1 in 5 adults have neck or shoulder pain.

Other risk factors include: poor posture, prolonged sitting, poor sleep position, injury and overuse, stress, and older age.

If you have high genetic risk or are experiencing symptoms, take action on modifiable factors like posture and sleep position.

What you can do

  • Cognitive-Behavioral Therapy (CBT)
    Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.
  • Low-Level Laser Therapy (LLLT)
    Use a low-level laser therapy device, as directed by its manual or a healthcare professional, on the affected area.
  • Massage 30 minutes
    Choose a type of TA massage that suits your specific needs, such as Swedish for relaxation or deep tissue for muscle tension.
From your Pain report
Cluster HeadachesMore likely
More likely to have cluster headaches based on 980 genetic variants we looked at
Your risk is greater than 82% of the population and lower than 18% of the population.

What this actually is

A cluster headache is a type of severe headache with bouts of frequent attacks, known as cluster periods.

Attacks may be triggered by: Alcohol High altitudes Bright light Heavy physical activity Heat Eating foods high in nitrites Certain medicines Illicit drugs like cocaine Some of the risk factors for cluster headaches include: Male sex Age 20 to 40 Smoking Genetics Genetics may explain about 25% of the differences in people’s odds of cluster headaches [R, R].

What you can do

  • Acupuncture
    Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.

Ask your clinician about

  • Magnesium

Named only. Marrow gives no dose and does not recommend these.

From your Pain report
Chronic PainMore likely
More likely to experience chronic pain based on 611,315 genetic variants we looked at
Your risk is greater than 80% of the population and lower than 20% of the population.

What this actually is

Key Takeaways: About 1 in 5 Americans report experiencing some form of chronic pain.

Risk factors include being female, older age, poverty, previous injury, mental health problems, and your genetics.

With a high genetic risk, you may want to be more mindful of other factors that can increase risk.

What you can do

  • Cognitive-Behavioral Therapy (CBT)
    Engage actively in exercises assigned by your therapist both during sessions and as homework to apply CBT strategies to daily life.
  • Biofeedback
    Practice the techniques learned during sessions at home daily to improve symptoms and manage your condition.
  • Acupuncture
    Visit a licensed acupuncturist for a session, typically lasting between 30 to 60 minutes, once or twice a week.
From your Pain report
A further 4 results were also flagged for attention. They are listed below and explained in full in the technical version of this report.

Where your genetics are working for you

Not everything in a genetic report is a warning. These came back protective or better than average.

Joint PainLess likely
Less likely to have osteoarthritis based on 385,825 genetic variants we looked at
Your risk is greater than 1% of the population and lower than 99% of the population.

What this actually is

Key Takeaways: Osteoarthritis will affect the majority of people over the age of 55.

So, even with low genetic risk, the overall risk is still high for older people.

About 50% of the differences in people's chances of getting osteoarthritis may be due to genetics.

From your Pain report

Everything else that came back

The remaining results, grouped by what they mean. Every one of these is explained in full — with the genes and variants behind it — in the technical version of this report.

Worth a conversation with your doctor  (4)
  • Painful Bladder Syndrome — More likely
  • Fibromyalgia — More likely
  • Diabetic Neuropathy — More likely
  • Long COVID — More likely
Running above the typical range  (1)
  • TRPM8 (Pain) — Higher activity
Running below the typical range  (2)
  • TRPV1 (Pain) — Lower activity, 15th percentile
  • OPRM1 (Endorphins) — Lower activity
In line with most people  (17)
  • Back Pain — Typical likelihood, 76th percentile
  • Painful Intercourse — Typical likelihood, 74th percentile
  • Trigeminal Nerve Pain — Typical likelihood, 68th percentile
  • Muscle Pain — Typical likelihood, 68th percentile
  • Hip Pain — Typical likelihood, 64th percentile
  • Tension Headaches — Typical likelihood, 64th percentile
  • Chest Pain (Angina) — Typical likelihood, 52th percentile
  • Headache — Typical likelihood, 51th percentile
  • Knee Pain — Typical likelihood, 36th percentile
  • Toothache — Typical likelihood, 33th percentile
  • Stomach Pain — Typical likelihood, 27th percentile
  • Nerve Compression — Typical likelihood, 22th percentile
  • Mononeuropathy — Typical likelihood
  • Peripheral Neuropathy — Typical likelihood
  • Neuropathic Pain — Typical likelihood
  • CNR1 (Cannabinoids) — Typical activity
  • SCN9A (Pain) — Typical activity

What to do with this

Genetics is a predisposition, not a verdict. The single most useful thing you can do with this document is take it to a clinician and talk through the flagged findings — especially any that line up with symptoms you already have or conditions that run in your family. Nothing here changes: your DNA is the same at 60 as it is today, so this report does not expire.

Methodology

Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.

Limitations

This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.

Performing laboratory & attestation
Performing laboratoryGene by Gene, Ltd.
Laboratory address1445 North Loop West, Suite 760, Houston, TX 77008
CLIA certificationCLIA #45D1102202
CAP accreditationCAP #7212851 · accredited through 7 October 2027
Laboratory DirectorFeng Zhou, PhD, MB(ASCP)
Specimen typeBuccal (cheek) swab — genomic DNA
AccessionMRW-26-A03659
Date reported29 July 2026

This specimen was tested at Gene by Gene, Ltd., 1445 North Loop West, Suite 760, Houston, TX 77008, under CLIA #45D1102202 and CAP #7212851. Laboratory Director: Feng Zhou, PhD, MB(ASCP). Marrow Health is not a clinical laboratory and does not perform testing; Marrow prepares and delivers this report from data produced by the performing laboratory named above. Report generated 29 July 2026 · Accession MRW-26-A03659 · © 2026 Marrow Health.