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Genomics · Genetic Reports · Precision Wellness

Perimenopause

Personalized Genetic Report
Symptoms & ComplaintsHealth RisksLab Markers
Sample ClientReport date: 29 July 2026
Genomics · Genetic Reports · Precision Wellness
Marrow Health Laboratories
Marrow
Accession #: MRW-26-54C1D4
Report type: Summary Report
Report status: FINAL

Specimen and client information

Client
Sample Client
Specimen type
Buccal (cheek) swab
Date reported
29 July 2026
Accession
MRW-26-54C1D4
Panel
Perimenopause
Results scored
27
Need attention
4
Report
Summary Report

What this report covers

Symptoms & Complaints · Health Risks · Lab Markers

About this report

This report reads your DNA and sorts every result into one of five plain-language groups, so you can see at a glance what deserves attention and what does not. Nothing here is a diagnosis. A flagged result means your genetics place you above or below the average person for that trait — a reason to ask a question, not a reason to worry.

What each result group means

Worth a conversation with your doctor
These came back with a higher genetic predisposition than most people. That is not a diagnosis — it means these are the ones worth raising at your next appointment.
Running above the typical range
Your genetics point to these sitting higher than average. Often useful to know, sometimes worth monitoring.
Running below the typical range
Your genetics point to these sitting lower than average. Same idea — context, not alarm.
Working in your favour
Good news. Your genetics look protective or better than average here.
In line with most people
Nothing unusual. These were tested and came back typical — worth having on record.

Your results at a glance

How to read this. A result being flagged does not mean you have a condition — it means your genetics put you above or below the average person for that trait. Of the 27 results here, 4 came back worth discussing with a clinician and 3 came back in your favour. Bring this document to your appointment.

What this package looks at

Perimenopause — Genetic factors significantly influence how women experience the menopausal transition, affecting both symptom severity and health risks. This comprehensive report examines genetic variants associated with common perimenopausal symptoms, increased health risks during this

What you can actually do

These are ordered by how closely they relate to your flagged results — not generic health advice. Marrow does not prescribe, dose, or tell you to take anything. Diet and lifestyle changes are listed first because they are yours to make. Anything you would swallow is listed separately, by name only, as something to raise with a clinician who knows your history and your medications.

Changes you can make yourself

1
Interpersonal Therapy50 minutes

Engage in weekly 50-minute sessions with a certified therapist trained in interpersonal therapy for a duration of TA 12-16 weeks.

Relates to: Low Mood
relevance
2
Psychodynamic Therapy

Schedule and attend weekly sessions with a trained psychodynamic therapist for a minimum duration of 6 months to several years, depending on individual needs and progress.

Relates to: Low Mood
relevance
3
Sunlight Exposure20 minutes

Expose your skin to direct sunlight for about 10-30 minutes several times per week, preferably during midday TA when the sun is strongest.

Relates to: Low Mood
relevance
4
Strength Training

Engage in strength training exercises, such as weight lifting or bodyweight exercises, for 60 minutes per session, TA 2 to 3 times per week.

Relates to: Low Mood, Menopause Symptoms
relevance
5
Probiotics
Relates to: Low Mood
relevance
6
Cherries

Incorporate a serving of cherries, which is about 1 cup or 21 cherries, into your daily diet.

Relates to: Low Mood, Irritability
relevance
7
Morning Bright Light Therapy20 minutes

Expose yourself to a light therapy box, which mimics natural sunlight, for about 20-30 minutes each morning TA within the first hour of waking up.

Relates to: Low Mood
relevance
8
Progressive Muscle Relaxation10 minutes

TA the muscles in your feet for 5 seconds, then relax for 30 seconds, and progressively work your way up through the major muscle groups of your body, tensing then relaxing each for 5 and 30 seconds respectively.

Relates to: Low Mood, Menopause Symptoms
relevance
9
Sleep for 7+ Hours

Ensure you allocate enough time in your schedule to achieve a minimum of 7 hours of sleep each night.

Relates to: Low Mood, Sexual Dysfunction, Irritability
relevance
10
Yoga30 minutes

Practice yoga for at least 20 to 30 minutes a day, most days of the week.

Relates to: Low Mood, Menopause Symptoms, Irritability, Sexual Dysfunction
relevance

Worth asking your clinician about

These came up in the research behind your flagged results. They are listed by name so you can ask about them. Marrow is not recommending them, and gives no dose. Supplements interact with prescription medication and with each other — that conversation belongs with your clinician.

1
St. John's Wort
Relates to: Low Mood, Menopause Symptoms
relevance
2
Tryptophan
Relates to: Low Mood, Menopause Symptoms
relevance
3
Methylfolate
Relates to: Sexual Dysfunction, Low Mood
relevance
4
Green Tea
Relates to: Low Mood
relevance

Your headline findings

Of the 27 results in this package, these 4 came back furthest from the population average. Each one below explains what it is, where you sit, and which report it came from. Start here.

Menopause SymptomsMore likely
Higher predisposition than 99% of people
Your result sits higher than 99% of the population.

What this actually is

Genetics plays a role in the age at which menopause starts and the severity of symptoms.

For example, genetic variations that influence the metabolism of sex hormones are associated with the frequency and severity of hot flashes.

Women often follow a similar pattern as their mothers or sisters.

What you can do

  • Yoga 30 minutes
    Practice yoga for at least 20 to 30 minutes a day, most days of the week.
  • Mediterranean Diet
    Limit red meat to a few times a month and include a moderate amount of dairy products.

Ask your clinician about

  • St. John's Wort

Named only. Marrow gives no dose and does not recommend these.

From your Perimenopause report
Heavy SweatingMore likely
More likely to have hyperhidrosis based on 104 genetic variants we looked at
Your risk is greater than 91% of the population and lower than 9% of the population.

What this actually is

Key Takeaways: Genes that affect excessive sweating may influence nerve function and chemical messengers.

Excessive sweating can impact quality of life and cause undue stress and anxiety.

If you have symptoms, you may want to consult your doctor to rule out other conditions.

What you can do

  • Yoga 30 minutes
    Practice yoga for at least 20 to 30 minutes a day, most days of the week.
  • Limit Manganese Exposure
    Avoid consuming water with high levels of manganese by using filters certified to remove it, especially if your water comes from a well.
  • Avoid Sugary Foods & Drinks
    Aim to do this daily for ongoing health benefits.
From your Perimenopause report
Sexual DysfunctionMore likely
More likely to have sexual dysfunction based on 1,671 genetic variants we looked at
Your risk is greater than 90% of the population and lower than 10% of the population.

What this actually is

Key Takeaways: About 40% of differences in people's chances of developing sexual dysfunction may be due to genetics.

Risk factors include getting older, hormone changes, stress, and certain health conditions.

If you are experiencing symptoms, check with your doctor for possible solutions.

What you can do

  • Sleep for 7+ Hours
    Ensure you allocate enough time in your schedule to achieve a minimum of 7 hours of sleep each night.

Ask your clinician about

  • Methylfolate
  • Zinc

Named only. Marrow gives no dose and does not recommend these.

From your Perimenopause report
Low MoodMore likely
More likely to have chronically low mood based on 84,205 genetic variants we looked at
Your risk is greater than 85% of the population and lower than 15% of the population.

What this actually is

Key Takeaways: About 40% of differences in people's odds of developing depression may be due to genetics.

It is more likely for young adults and the elderly but can affect people of all ages.

Other risk factors include traumatic and stressful events, serious medical conditions, and substance use problems.

What you can do

  • Interpersonal Therapy 50 minutes
    Engage in weekly 50-minute sessions with a certified therapist trained in interpersonal therapy for a duration of TA 12-16 weeks.
  • Psychodynamic Therapy
    Schedule and attend weekly sessions with a trained psychodynamic therapist for a minimum duration of 6 months to several years, depending on individual needs and progress.
  • Sunlight Exposure 20 minutes
    Expose your skin to direct sunlight for about 10-30 minutes several times per week, preferably during midday TA when the sun is strongest.
From your Perimenopause report

Where your genetics are working for you

Not everything in a genetic report is a warning. These came back protective or better than average.

Cognitive DeclineLess likely
Less likely to have cognitive decline based on 272,168 genetic variants we looked at
Your risk is greater than 1% of the population and lower than 99% of the population.

What this actually is

Mild cognitive decline is a normal part of aging that can affect cognitive functions such as memory, attention, and problem-solving.

About 60-70% of the differences in people’s cognitive decline may come from genetics.

For example, genetically high total and bioavailable testosterone may be causally associated with larger gray matter volume in men [R, R, R].

From your Perimenopause report
OverweightLess likely
Less likely to be overweight or obese based on 455,505 genetic variants we looked at
Your risk is greater than 1% of the population and lower than 99% of the population.

What this actually is

Up to 42% of adults and 19% of children in the US meet the medical criteria for obesity.

Weight gain affects conditions like high blood sugar and heart disease.

However, it is highly modifiable by diet and exercise.

From your Perimenopause report
Metabolic SyndromeLess likely
Less likely to have metabolic syndrome based on 636,870 genetic variants we looked at
Your risk is greater than 1% of the population and lower than 99% of the population.

What this actually is

Factors that might increase the risk of developing metabolic syndrome include: Age: Risk increases with age.

A history of diabetes in one's family.

A history of gestational diabetes or having given birth to a baby weighing more than 9 pounds.

From your Perimenopause report

Everything else that came back

The remaining results, grouped by what they mean. Every one of these is explained in full — with the genes and variants behind it — in the technical version of this report.

Running above the typical range  (4)
  • Irritability — Higher, 95th percentile
  • FSH — Higher levels
  • Testosterone (F) — Higher levels
  • Estradiol — Higher levels
In line with most people  (16)
  • Vaginal Atrophy — Typical likelihood, 67th percentile
  • Total Cholesterol — Typical levels, 61th percentile
  • Cardiovascular Disease — Typical likelihood, 60th percentile
  • Anxiety — Typical likelihood, 57th percentile
  • Type 2 Diabetes — Typical likelihood, 49th percentile
  • LDL Cholesterol — Typical levels, 44th percentile
  • Irregular Periods — Typical likelihood, 36th percentile
  • Osteoporosis — Typical likelihood, 33th percentile
  • Triglycerides — Typical levels, 16th percentile
  • Sleep Quality — Typical
  • TSH — Typical levels
  • Vitamin D — Typical need
  • HDL Cholesterol — Typical levels
  • Fasting Glucose — Typical levels
  • Red Blood Cells — Typical levels
  • Iron — Typical need

What to do with this

Genetics is a predisposition, not a verdict. The single most useful thing you can do with this document is take it to a clinician and talk through the flagged findings — especially any that line up with symptoms you already have or conditions that run in your family. Nothing here changes: your DNA is the same at 60 as it is today, so this report does not expire.

Methodology

Genotyping was performed on DNA extracted from a buccal (cheek) swab using a genome-wide array. Results are derived from peer-reviewed genome-wide association data and, where applicable, published clinical guidelines. Each report was scored independently against its own reference set. Percentile figures describe where your result sits relative to a reference population.

Limitations

This is a laboratory-developed test. It has not been cleared or approved by the U.S. Food and Drug Administration. Genotyping does not detect all variants in the genes assessed; the absence of a flagged result does not exclude risk. Predisposition is probabilistic and is modified by environment, lifestyle, ancestry and family history. Results must be interpreted by a qualified healthcare professional and must not be used alone to diagnose, treat, or alter any medication regimen. Marrow does not recommend, prescribe, or dose any supplement or medication.

Performing laboratory & attestation
Performing laboratoryGene by Gene, Ltd.
Laboratory address1445 North Loop West, Suite 760, Houston, TX 77008
CLIA certificationCLIA #45D1102202
CAP accreditationCAP #7212851 · accredited through 7 October 2027
Laboratory DirectorFeng Zhou, PhD, MB(ASCP)
Specimen typeBuccal (cheek) swab — genomic DNA
AccessionMRW-26-54C1D4
Date reported29 July 2026

This specimen was tested at Gene by Gene, Ltd., 1445 North Loop West, Suite 760, Houston, TX 77008, under CLIA #45D1102202 and CAP #7212851. Laboratory Director: Feng Zhou, PhD, MB(ASCP). Marrow Health is not a clinical laboratory and does not perform testing; Marrow prepares and delivers this report from data produced by the performing laboratory named above. Report generated 29 July 2026 · Accession MRW-26-54C1D4 · © 2026 Marrow Health.